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M9490758.TXT
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1994-09-24
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Document 0758
DOCN M9490758
TI Neutralizing and enhancing antibodies measured in complement-restored
serum samples from HIV-1-infected individuals correlate with
immunosuppression and disease.
DT 9411
AU Fust G; Toth FD; Kiss J; Ujhelyi E; Nagy I; Banhegyi D; National
Institute of Haematology, Blood Transfusion, and; Immunology, Budapest,
Hungary.
SO AIDS. 1994 May;8(5):603-9. Unique Identifier : AIDSLINE MED/94338595
AB OBJECTIVE: To study the association between the progression of HIV
disease and HIV neutralization and enhancement measured in the presence
of human complement. DESIGN: Two studies were performed: (1)
longitudinal measurement of the complement-dependent enhancing
antibodies in parallel with T-cell subset determination in 55 serum
samples from seven HIV-infected patients, and (2) determination of the
titres of neutralizing and enhancing antibodies in stored samples of 21
HIV-asymptomatic patients obtained between 1986 and 1987 and follow-up
of the patients until October 1992. METHODS: HIV-1 [human T-lymphotropic
virus (HTLV)IIIB strain, 100 median tissue culture infective dose
(TCID50)] was incubated with twofold dilutions of sera in the presence
of human complement (final dilution, 1:4) and added to MT-4 cells. HIV
growth was monitored daily for 5 days using the reclustering inhibition
and p24 immunofluorescence assays. RESULTS: A significant negative
correlation between the titres of enhancing antibodies and CD4+ cell
count was found in longitudinal measurements. In the prospective
studies, marked differences were observed between patients with
undetectable, low, or high titres of enhancing antibodies in the
clinical course of HIV disease: CD4+ cell counts and percentages
decreased more rapidly in the high titre group within 3 years. After 5
years, AIDS developed in five out of six patients in the high titre
group but only in five out of 15 of the low titre group (P < 0.05). A
similar difference was observed between patients with and without
neutralizing antibodies. CONCLUSIONS: Measurement of HIV neutralization
and enhancement in complement-containing serum samples using a
complement receptor carrying target may provide data of clinical
relevance. Neutralization appears to be associated with a favourable
prognosis whereas high titre enhancing antibodies predict rapid
progression of HIV disease.
DE Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/IMMUNOLOGY
Adolescence Adult *Complement Follow-Up Studies
Hemophilia/COMPLICATIONS Homosexuality Human HIV
Antibodies/BLOOD/*IMMUNOLOGY HIV
Infections/BLOOD/COMPLICATIONS/*IMMUNOLOGY HIV-1/*IMMUNOLOGY Leukocyte
Count Male Neutralization Tests Prognosis Risk Factors T4
Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).